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In the past 15 years Prof. Ari Rappoport, a tenured professor of Computer Sciences at the
Hebrew University of Jerusalem, has systematically and passionately researched the brain.
Using his computer and data management skills he has scanned, read, analyzed, dissected and integrated over 500,000 scientific articles, on a large variety of subjects, dating back over 50 years. This mammoth and unique effort has resulted in novel complete theories – all based on firm, existing scientific data – for the following diseases:
Each theory is complete, in the sense that it describes the mechanism of the disease, and
explains all major side effects. All theories are based on solid available scientific data. Each one
points to a target, and suggests a treatment. In some cases these treatments already exist for unrelated disorders. The theory for each of the above diseases is explained in a detailed scientific article, with full references.Prof Roger Kornberg of Stanford University and a Nobel Prize laureate is intimately familiar with the work of Prof Rappoport. He has recently written about it:
“The work of Rappoport is extraordinary. Although I am not a neuroscientist I recognize the magnitude of his achievement, and I have consulted world-leading neuroscientists of my acquaintance who can attest to the depth and importance of the work.
Rappoport has done something unique in the history of life science. He devoted decades to a single-minded, comprehensive study of the literature on the brain. It is a vast literature, beyond the capacity of any practicing scientist to study in detail, what with the demands of teaching, administration, and experimenting on any particular aspect. Rappoport brought exceptional insight and analytical ability to the entirety of brain science, and derived unprecedented understanding and predictive power, as well as detailed proposals for addressing nearly a dozen of the most serious diseases.
I submitted his essay on Alzheimers Disease to the leading publication, the Annual Review of Biochemistry, where it was subjected to critical review and immediately accepted and published. Rappoport’s oeuvre includes ten equally remarkable reviews, each drawing upon many hundreds of original articles and synthesizing the contents in cogent hypotheses and proposals for next steps.”
It may seem unbelievable that someone who is not a doctor or biologist can produce updated,
scientifically sound theories. The opposite is true. Such an extensive overview can only be achieved by full devotion to the cause.
It takes an outsider, and a very determined and capable one, to absorb the totality and extract the ‘gems’ hidden in it.
Bridging the gap between groundbreaking ideas and widespread acceptance is a challenge, particularly within the scientific and pharmaceutical communities. These fields often rely on classical frameworks, established channels, and input from well-recognized institutions. This challenge is further compounded by the current lack of complete theories for many of the brain disorders under discussion. As a result, gaining recognition and engagement for Prof. Rappoport’s work – regardless of its validity and transformative potential – is far from a simple or straightforward endeavor.