This stress impairs the function of sex steroids crucial for early brain development, leading to the developmental challenges seen in autism.

The theory begins with the observation that stress-related hormones, particularly CRH (corticotropin-releasing hormone) and ACTH (adrenocorticotropic hormone), are elevated in infants who later develop autism. These hormones are released in response to stress, and their excessive levels interfere with the normal activity of sex steroids, which play a vital role in shaping neural development during the first few months of life.

Sex steroids, especially in males, are critical for organizing the brain’s structure and function in the early stages of life. When their activity is disrupted by stress hormones, the brain fails to develop properly, resulting in the cognitive and behavioral traits characteristic of autism. This mechanism provides a biological explanation for the observed gender disparity in autism prevalence, with males being more frequently affected than females.

The author suggests a simple diagnostic approach: measuring stress hormone levels in newborns as an indicator of autism risk. High levels of ACTH in particular could serve as a biomarker, enabling early identification of at-risk infants. This test, combined with monitoring developmental milestones, could allow for earlier intervention and support.

In terms of treatment, the theory proposes the use of DHT (dihydrotestosterone), a sex steroid hormone that can counteract the effects of elevated stress hormones. Administering DHT via a skin patch in the early months of life could restore the balance of hormonal activity, potentially mitigating the developmental impairments associated with autism. This approach is non-invasive and safe, making it a promising avenue for future research.

The author emphasizes the importance of conducting controlled studies to validate this theory and evaluate the proposed treatment. By systematically testing ACTH levels and the effects of DHT therapy in newborns, researchers could provide critical evidence for this innovative approach. Such studies would represent a significant step toward understanding and addressing autism at its root cause.

In conclusion, the author’s theory offers a groundbreaking perspective on autism, linking early-life stress to hormonal disruptions that impair brain development. By identifying biomarkers and exploring targeted hormone therapy, this approach has the potential to transform the diagnosis and treatment of autism, providing hope for improved outcomes in affected individuals.